کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10547765 965107 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new optimization strategy for gaseous phase sampling by an internally cooled solid-phase microextraction technique
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A new optimization strategy for gaseous phase sampling by an internally cooled solid-phase microextraction technique
چکیده انگلیسی
This study describes a new optimization strategy for internally cooled solid-phase microextraction based on a multivariate approach. The coating temperature was changed in an extraction while manipulating the extraction times to improve the extraction of compounds with different volatilities. Polycyclic aromatic hydrocarbons (PAHs) and phthalic acid esters (PEs) and adipate were used as model compounds in this study. The optimization strategy was in two steps: (1) multivariate optimization of extraction time and initial coating temperature and (2) multivariate optimization of total extraction time and the time required to cool the coating to a lower temperature as determined in step 1. The observed analytical response in relation to the coating temperature was found to be dependent on the analyte volatility and size. The optimized extraction condition for PEs was 23 min extraction while maintaining the coating at 140 °C, followed by 7 min of cooling the coating at 10 °C. For the PAHs the coating temperature was maintained at 60 °C for the first 20 min and at 5 °C in the last 20 min of extraction. Comparisons have been made between the proposed optimized conditions with the conventional internally cooled fiber approach and the results thoroughly discussed. The proposed optimization strategy was found to be more effective for all the analytes, especially for the semi-volatiles, compared to the conventional method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1218, Issue 3, 21 January 2011, Pages 367-372
نویسندگان
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