کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10552278 967197 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enantiomeric determination of ephedrines and norephedrines by chiral derivatization gas chromatography-mass spectrometry approaches
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Enantiomeric determination of ephedrines and norephedrines by chiral derivatization gas chromatography-mass spectrometry approaches
چکیده انگلیسی
Concerned with variations in abuse potential and control status among various isomers of ephedrines and norephedrines, this study was conducted to develop an effective method for the simultaneous analysis of eight ephedrine-related compounds along with structurally similar cathinones. Among various approaches studied, a 60-m HP-5MS (0.25 mm i.d., 0.25 μm film thickness) was successfully used to characterize the following compounds that were derivatized with (−)-α-methoxy-α-trifloromethylphenylacetic acid (MTPA): (+)-cathinone, (−)-cathinone, (+)-norephedrine, (−)-norephedrine, (+)-norpseudoephedrine, (+)-ephedrine, (−)-ephedrine, (−)-pseudoephedrine, (+)-pseudoephedrine. (−)-Cathine standard was not available, but should also be resolvable under this analytical procedure. This method was successfully applied to the analysis of selected cold remedies for characterizing the enantiomeric compositions of the compounds present in these samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 825, Issue 1, 15 October 2005, Pages 88-95
نویسندگان
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