کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10553564 | 967830 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stability of epidoxorubicin in solid state
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The influence of temperature and relative air humidity on the stability of epidoxorubicin hydrochloride (EP) was investigated. The degradation of the substance studied was determined: (a) in dry air at 393 K, (b) at relative air humidity â¼76% at 333 K, 343 K, 353 K, 363 K and 373 K, (c) in the relative air humidity range 50-90% at 363 K. The degradation of EP in the atmosphere of increased relative air humidity was a first-order reaction relative to substance concentration and in dry, hot air (RH 0%; 393 K) is a reversible first-order reaction relative to substance concentration. The dependences ln k = f(1/T) and ln k = f(RH%) were described by the equation: ln k = (35.1 ± 10.9) â (16,250 ± 3823)(1/T) and ln k = (3.79 ± 3.34) Ã 10â2 (RH%) â (12.9 ± 2.4), respectively. The kinetic and thermodynamic parameters of EP degradation were calculated. The parameters of separation were following: LiChrospher RP-18 column, 5 μm, 250 mm Ã 4 mm; mobile phase: the mixture of equal volume of acetonitrile and the solution containing 2.88 g lâ1 of sodium laurisulfate and 2.25 ml lâ1 of phosphoric acid (V) 85%; flow rate: 1.0 ml minâ1; UV detection - 254 nm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 54, Issue 4, 25 March 2011, Pages 869-872
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 54, Issue 4, 25 March 2011, Pages 869-872
نویسندگان
Agnieszka Sobczak, Anna JeliÅska, Monika LeÅniewska, Artur Firlej, Irena Oszczapowicz,