کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10553666 | 967888 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of azithromycin by ion-pair HPLC with UV detection
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Determination of azithromycin by ion-pair HPLC with UV detection Determination of azithromycin by ion-pair HPLC with UV detection](/preview/png/10553666.png)
چکیده انگلیسی
An ion-pair reversed phase high performance liquid chromatographic method with UV detection was developed for the determination of azithromycin using sodium heptanesulfonate as an ion-pair reagent. The mobile phase consisted of a mixture of ammonium dihydrogen phosphate (0.045 M, pH 3.0 adjusted by phosphoric acid):acetonitrile 47:15 (v/v) and the concentration of sodium heptanesulfonate in the aqueous phase was 0.002 M. UV detection was performed at 210 nm. The chromatographic column was Dikma Technologies Diamonsil C18 column, 5 μm 150 mm Ã 4.6 mm, which was maintained at 25 °C. Applying the method to a stability study of azithromycin eye drops, it was found that the related substance could be detected and the profile of the AZM peak was symmetrical and the column efficiency was high. Accordingly, it is suitable for the routine analysis and stability testing of azithromycin preparations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 49, Issue 3, 5 April 2009, Pages 811-815
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 49, Issue 3, 5 April 2009, Pages 811-815
نویسندگان
Zi Yi Yang, Lin Wang, Xing Tang,