Use of reversed-phase liquid chromatography for determining the lipophilicity of α-aryl-N-cyclopropylnitrones

In addition, the comparative molecular similarity indices analysis (CoMSIA) method was also applied to correlate the log kw retention parameter of the compounds with their molecular fields. Statistically significant CoMSIA models were obtained between log kw and the hydrophobic and steric molecular fields of our compounds. The CoMSIA models describe how the structure of the nitrone derivatives influences (through hydrophobic and steric interactions with the stationary phase) the chromatographic retention of the compounds.