کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10553906 | 967942 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Validation of quantitative NMR
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Validation of quantitative NMR Validation of quantitative NMR](/preview/png/10553906.png)
چکیده انگلیسی
Here, a validated protocol for quantitative high resolution 1H-NMR using single pulse excitation is described that has been confirmed by national and international round robin tests. It considers all issues regarding linearity, robustness, specificity, selectivity and accuracy as well as influences of instrument specific parameters and the data processing and evaluation routines. This procedure was tested by the investigation of three different 5-model-compound mixtures. As a result of the round robin tests using the proposed protocol it was found that the maximum combined measurement uncertainty is 1.5% for a confidence interval of 95%. This applies both for the determination of molar ratios and of the amount fractions of the various components. Further, the validation was extended to purity determinations of substances as shown for 1,8-epoxy-p-menthane (cineole).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 38, Issue 5, 10 August 2005, Pages 813-823
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 38, Issue 5, 10 August 2005, Pages 813-823
نویسندگان
F. Malz, H. Jancke,