کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10554017 | 967949 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Automated system for release studies of salicylic acid based on a SIA method
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The aim of this work was to describe a fully automated system for the in vitro release testing of semisolid dosage forms based on SIA technique. The system was tested for monitoring release profiles of different ointments containing 3% of salicylic acid (Belosalic, Diprosalic, Triamcinolone S). The native fluorescence of salicylic acid was used for fluorimetric detection. Phosphate buffer pH 7.4 was the receptor medium; samples were taken at 10 min intervals during 6 h of the release test; and each test was followed by calibration with five standard solutions. The linear calibration range was 0.05-10 μg mlâ1 (r = 0.9996, six standards); the maximal SIA sample throughput for this system was 120 hâ1, sample volume being 50 μl and flow rate 50 μl sâ1. The detection limit for salicylic acid was 0.01 μg mlâ1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 37, Issue 5, 29 April 2005, Pages 893-898
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 37, Issue 5, 29 April 2005, Pages 893-898
نویسندگان
J. Klimundová, H. SklenáÅová, U.F. Schaefer, P. Solich,