کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10554043 967949 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LC-MS determination of MPTP at sub-ppm level in pethidine hydrochloride
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
LC-MS determination of MPTP at sub-ppm level in pethidine hydrochloride
چکیده انگلیسی
An HPLC-MS with electrospray ionisation method for the determination of MPTP at sub-ppm level in pethidine hydrochloride has been developed and validate. Ionisation is performed by positive-ion electrospray and the quadrupole filter mass spectrometer is operated in the single ion recording mode. Chromatographic separation was achieved in gradient elution using a symmetry C18, 5 μm, 150 mm × 2.1 mm i.d. The mobile phase comprised water containing 0.1% formic acid (v/v) and acetonitrile containing 0.1% formic acid (v/v). The method showed to be linear in the range between 0.2 and 2.2 ng/ml, the estimated LOD was lower than 0.1 ng/ml and the LOQ was lower than 0.2 ng/ml.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 37, Issue 5, 29 April 2005, Pages 1089-1093
نویسندگان
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