کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10554100 967951 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and validation of HPLC methods for the enantioselective analysis of bambuterol and albuterol
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Development and validation of HPLC methods for the enantioselective analysis of bambuterol and albuterol
چکیده انگلیسی
Suitable HPLC methods for the direct separation of bambuterol and albuterol enantiomers were developed. The enantioseparation was tested on numerous commercial chiral HPLC columns. For bambuterol the most convenient separation was determined on amylose Chiralpak AD column, and for albuterol on vancomycine Chirobiotic V column. The mobile phase compositions were systematically studied to obtain the optimal chromatographic methods. Validation of methods in selected conditions shows that the chosen methods are selective and precise with linear response of detector for both pairs of enantiomers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 36, Issue 5, 4 January 2005, Pages 1003-1010
نویسندگان
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