کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10554361 | 967959 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Measurement of lactose crystallinity using Raman spectroscopy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Raman spectroscopy (RS) was used to determine the crystallinity of lactose (a commonly used carrier in dry powder inhaler (DPI) formulations). Samples of α-lactose monohydrate and amorphous lactose were prepared using ethanol precipitation and lyophilisation respectively. The anomeric forms were confirmed using DSC at a rate of 10 °C/min and heated to 250 °C. The Raman spectra of both α-lactose monohydrate and amorphous lactose were obtained. Distinguishable differences were seen between the two spectra including peak areas and intensities. Depolarisation ratios (Ï) of each form were then determined to identify the crystallinity of the lactose carrier samples. At the prominent Raman bands 865 and 1082 cmâ1, significant differences in Ï values were observed for crystalline (0.80 ± 0.07, 0.89 ± 0.06 respectively) and amorphous samples (0.44 ± 0.07, 0.51 ± 0.10).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 38, Issue 1, 1 June 2005, Pages 186-190
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 38, Issue 1, 1 June 2005, Pages 186-190
نویسندگان
Bridget M. Murphy, Stuart W. Prescott, Ian Larson,