کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10554438 967963 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spectrophotometric determination of oxiconazole in topical lotion using methyl orange
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Spectrophotometric determination of oxiconazole in topical lotion using methyl orange
چکیده انگلیسی
A spectrophotometric method is described for the determination of oxiconazole in raw material and in topical lotion. This method is based on the reaction of the oxiconazole with methyl orange in buffered aqueous solution of citric acid at pH 2.3. The chromogen, being extractable with dichloromethane, could be measured quantitatively with maximum absorption at 427 nm. The Lambert-Beer law was obeyed in the concentration range of 4.0-14.0 μg ml−1. A prospective validation of the method showed that the method was linear (r = 0.9995), precise (intra-day: CV = 1.57% and inter-day: CV = 1.50%) and accurate (mean recoveries: 99.69%). The results compared favourably with those of the HPLC method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 37, Issue 4, 1 April 2005, Pages 639-642
نویسندگان
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