Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography

High-performance liquid chromatography (HPLC) was used for the simultaneous quantification of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride. Both compounds were detected at the wavelength of 214 nm. The influence of the mobile phase and the detection wavelength was evaluated and optimized. This method was used to assay various samples from studies of the commercial preparation Semprex®-D capsules. The method was found to be accurate, specific, selective, rapid, and versatile for use in routine quality control analyses.