کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10554453 967963 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of diltiazem and its related substances by HPLC and HPLC/MS
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Analysis of diltiazem and its related substances by HPLC and HPLC/MS
چکیده انگلیسی
Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S,3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, B, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 37, Issue 4, 1 April 2005, Pages 695-701
نویسندگان
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