Proteomic analysis of colony morphology variants of Burkholderia pseudomallei defines a role for the arginine deiminase system in bacterial survival

► B. pseudomallei undergoes morphotypic switching in response to stress. ► Numerous proteins were differentially expressed by isogenic morphotypes. ► Types II and III over-expressed arginine deiminase (ArcA) and carbamate kinase (ArcC). ► Exposure of parental type I to acid led to increased transcription of arcA and arcC. ► arcA and arcC defective mutants had reduced survival in acid.