Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytes

► Vav1 sustains the ATRA-induced maturation of APL-derived cells. ► Vav1 is involved in determining the nuclear amount of DNA-interacting proteins. ► Vav1 drives inside the nucleus molecules involved in mRNA production and stability. ► Since mRNA fate is altered in tumors, Vav1 may be a target for anti-cancer strategies.