Venomics and antivenomics profiles of North African Cerastes cerastes and C. vipera populations reveals a potentially important therapeutic weakness

► C. cerastes venom comprises a low complexity proteome. ► C. cerastes venom toxins mainly target the hemostatic system. ► Anti-Cc antivenoms effectively cross-reacted against geographic variants. ► Anti-Cc antivenoms showed low degree of cross-reactivity against C. vipera toxins.