Lipidomic investigations for the characterization of circulating serum lipids in multiple sclerosis

► An LC-MS based lipidomics approach was carried out to investigate serum lipids in multiple sclerosis. ► Ten significant lipids were highlighted and tentatively identified by accurate mass and MS/MS experiments. ► Our data show evidence in serum of a relationship between LysoPC/PC ratio and multiple sclerosis. ► There may be an altered phospholipid metabolism in multiple sclerosis that can be evaluated in serum.