Tick-borne diseases in cattle: Applications of proteomics to develop new generation vaccines

► New vaccines for TBDs require more knowledge on tick-pathogen-vector interactions. ► In vivo/in vitro biological samples from ruminant and tick origin are required. ► The use of several “Omics” strategies improves knowledge on pathogens' biology. ► Effective integration of systems biology allows a targeted choice of biomarkers. ► New vaccines will be more effective and less expensive for worldwide application.