Current advances in proteomic analysis of (fatty) liver

► Liver is a central organ in animals but its study by proteomic approaches is still poorly documented. ► Liver proteome mapping is still far to be complete in farm animals. ► In chicken, proteomic analysis revealed a change in the metabolic orientation of the liver with age. ► Liver proteome analyses provide new insights in ketosis and feed restriction in dairy cows. ► Technological quality variability of duck fatty liver is partly explained by proteomic studies.