Variable regions in the sushi domains 6-7 and 19-20 of factor H in animals and human lead to change in the affinity to factor H binding protein of Borrelia

► Borrelia binds factor H (fH) to evade complement system. ► Binding is mediated through borrelial surface proteins like BbCRASP-1. ► Differential binding of BbCRASP-1 to sushi domains of fH from animals is presented in this work.