Membrane proteins of human fetal primitive nucleated red blood cells

► First report on membrane proteome of human fetal red blood cells (FNRBCs) ► Unique-to-FNRBC plasma membrane proteins compared to adult RBCs are identified. ► Potential surface-antigens for enrichment of FNRBCs from maternal blood are identified. ► RT-PCR and Immunocytochemistry validated 2DLCMS/MS identifications. ► 171 surface proteins of adult RBCs are not present in FNRBCs.