Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach

► Multidisciplinary study of a venom composition combining biochemistry and transcriptomics analysis. ► Injectable cone snail venom comprehensive analysis. ► Identification of a high ratio of propeptides. ► Discovery of novel conotoxins of the A-, M- and O1-superfamilies. ► Identification of proteins in a injected venom.