Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism

► Comparative proteomic analysis was applied to investigate changes in protein expression in an attenuated line of Leishmania infantum. ► 18 protein species were found to be significantly and reproducibly modulated. ► Several changes were in components of the thiol-redox control system. ► The attenuated line was shown to be more susceptible to oxidative stress.