کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10559583 969642 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quantification of N-acetylcysteine in pharmaceuticals using cobalt phthalocyanine modified graphite electrodes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Quantification of N-acetylcysteine in pharmaceuticals using cobalt phthalocyanine modified graphite electrodes
چکیده انگلیسی
Flow injection analysis (FIA) with amperometric detection was employed for the quantification of N-acetylcysteine (NAC) in pharmaceutical formulations, utilizing an ordinary pyrolytic graphite (OPG) electrode modified with cobalt phthalocyanine (CoPc). Cyclic voltammetry was used in preliminary studies to establish the best conditions for NAC analysis. In FIA-amperometric experiments the OPG-CoPc electrode exhibited sharp and reproducible current peaks over a wide linear working range (5.0 × 10−5-1.0 × 10−3 mol L−1) in 0.1 mol L−1 NaOH solution. High sensitivity (130 mA mol−1 cm2) and a low detection limit (9.0 × 10−7 mol L−1) were achieved using the sensor. The repeatability (R.S.D.%) for 13 successive flow injections of a solution containing 5.0 × 10−4 mol L−1 NAC was 1.1%. The new procedure was applied in analyses of commercial pharmaceutical products and the results were in excellent agreement with those obtained using the official titrimetric method. The proposed amperometric method is highly suitable for quality control analyses of NAC in pharmaceuticals since it is rapid, precise and requires much less work than the recommended titrimetric method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 83, Issue 5, 15 February 2011, Pages 1701-1706
نویسندگان
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