کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10559729 | 969665 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Facile synthesis of fluorescent Au@SiO2 nanocomposites for application in cellular imaging
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel fluorescent Au@SiO2 nanocomposite, with average size of ca. 30Â nm in the diameter, was prepared via a simple microemulsion method. Additionally, transmission electron microscopy (TEM), UV-Vis absorption spectra, Fourier transform infrared (FT-IR) spectra and fluorescence spectra were used to characterize this nanocomposite. This newly synthesized, silica-wrapped, gold nanocluster has the following advantages: good water solubility, exceptional biocompatibility, favorable surface properties and excellent fluorescence properties. Because of these advantages, a Au@SiO2 nanocomposite is exceptionally suitable for biological applications. In this study, cellular imaging, as a form of biological application, has been fully investigated, and it was discovered, after covalent conjugation of folic acid (FA), that the nanocomposite effectively recognized over expressed folic acid receptors (FARs) on the HeLa cell's surface. Therefore, this fluorescent Au@SiO2 nanocomposite could be used as a new fluorescent probe for selective biological imaging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 85, Issue 5, 15 October 2011, Pages 2695-2699
Journal: Talanta - Volume 85, Issue 5, 15 October 2011, Pages 2695-2699
نویسندگان
Zhengyong Zhang, Peng Zhang, Kai Guo, Guohai Liang, Hui Chen, Baohong Liu, Jilie Kong,