Surface-functionalized silica-coated gold nanoparticles and their bioapplications

Monodisperse Au at SiO2 nanoparticles has been functionalized with carboxylic groups for further bioconjugation with amino-terminated oligonucleotides. The oligonucleotide-modified Au at SiO2 nanoprobes have been applied in the fast colorimetric DNA based on the sequence-specific hybridization properties of DNA. Self-assembling behavior of Au at SiO2 nanoparticles was also investigated.