کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10561386 | 969771 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids](/preview/png/10561386.png)
چکیده انگلیسی
The voltammetric behavior of cefixime was studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The oxidation of cefixime was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. Different parameters were tested to optimize the conditions for the determination of cefixime. The dependence of current intensities and potentials on pH, concentration, scan rate, nature of the buffer was investigated. According to the linear relationship between the peak current and the concentration, differential pulse (DPV) and square wave (SWV) voltammetric methods for cefixime assay in pharmaceutical dosage forms and biological fluids were developed. For the determination of cefixime were proposed in acetate buffer at pH 4.5, which allows quantitation over the 6Â ÃÂ 10â6-2Â ÃÂ 10â4Â M range in supporting electrolyte and spiked serum sample; 8Â ÃÂ 10â6-2Â ÃÂ 10â4Â M range in urine sample; 6Â ÃÂ 10â6-1Â ÃÂ 10â4Â M range in breast milk samples for both techniques. The repeatability, reproducibility, precision and accuracy of the methods in all media were investigated. No electroactive interferences from the excipients and endogenous substances were found in the pharmaceutical dosage forms and in the biological samples, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 67, Issue 4, 15 October 2005, Pages 703-712
Journal: Talanta - Volume 67, Issue 4, 15 October 2005, Pages 703-712
نویسندگان
AyÅegul Golcu, Burcu Dogan, Sibel A. Ozkan,