کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10561435 969774 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode
چکیده انگلیسی
The electrochemistry of metronidazole, 1-(hydroxyethyl)-2-methyl-5-nitroimidazole, was investigated at a carbon fiber microdisk electrode in pH 9 Britton Robinson buffer. Under these conditions, the reduction of metronidazole is controlled by both mass transport to the microdisk and adsorption with an equilibrium constant of 4 × 103 mol−1 dm3 and a saturation coverage of 0.88 × 10−8 mol cm−2. The adsorption and accumulation of metronidazole on the surface of the carbon fiber allows its determination at low concentrations by square wave adsorptive stripping voltammetry. A detection limit for metronidazole of 5 × 10−7 mol dm−3 and a R.S.D. of 3.7% at 1 × 10−6 mol dm−3 (n = 4) were obtained with a two electrode system with no stirring during the accumulation step. Based on this method, a simple procedure for the determination of metronidazole in urine is described which requires no pre-treatment of the sample before analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 66, Issue 4, 15 May 2005, Pages 869-874
نویسندگان
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