کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10561602 969779 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
چکیده انگلیسی
A simple, fast and sensitive square-wave voltammetric (SWV) method for the determination of trace amounts of Captopril in pharmaceutical formulation and reconstituted serum is reported. A three-electrode system containing the static mercury drop electrode (SMDE) working electrode, Pt auxiliary electrode and Ag/AgCl reference electrode was used throughout. Sodium sulfite was used as both supporting electrolyte and oxygen removing agent. No nitrogen purging is needed for oxygen removal from sample solution. Calibration graph showed good linearity in the concentration range of 0.5-50.0 μg mL−1 of Captopril and regression coefficient of 0.9957 is obtained. R.S.D. for eight replicate measurements and LOD of the proposed method are 1.2% and 6.28 × 10−3 μg mL−1, respectively. The effect of various parameters (equilibration time, scan increment, pulse height, drop size, frequency and sodium sulfite concentration) on the determination were investigated. The procedure was successfully applied to the determination of Captopril in pharmaceutical formulation and reconstituted serum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 65, Issue 3, 15 February 2005, Pages 776-780
نویسندگان
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