کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10561614 | 969779 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reanalysis of the testosterone displacement from its HSA binding site by DHEA using competitive Langmuir isotherm
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reanalysis of the testosterone displacement from its HSA binding site by DHEA using competitive Langmuir isotherm Reanalysis of the testosterone displacement from its HSA binding site by DHEA using competitive Langmuir isotherm](/preview/png/10561614.png)
چکیده انگلیسی
In a previous manuscript [C. Andre, A. Berthelot, J.F. Robert, M. Thomassin, Y.C. Guillaume, J. Pharm. Bio. Med., in press], the Mg2+ effect on the testosterone displacement equilibrium from its human serum albumin (HSA) binding site by DHEA was investigated using a thermodynamic approach. In this paper, a novel concept based on the competitive Langmuir distribution isotherms was proposed to calculate the association constant of the HSA-hormone binding and to confirm the Mg2+ role on the testosterone displacement equilibrium from its HSA binding site by DHEA. Thus, both the HSA-hormone binding and the displacement equilibrium processes were reanalysed. The results obtained confirmed that:
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 65, Issue 3, 15 February 2005, Pages 814-818
Journal: Talanta - Volume 65, Issue 3, 15 February 2005, Pages 814-818
نویسندگان
Claire André, Alain Xicluna, Jean-François Robert, Mireille Thomassin, Yves-Claude Guillaume,