کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10565421 | 971699 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proteomic insights into ubiquitin and ubiquitin-like proteins
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کلمات کلیدی
PTMSUMOERADUblDUBDeubiquitinatingESI-MS/MS - ESI-MS / MSMS/MS - MS / MSpost-translational modification - اصلاح post-translationalEndoplasmic reticulum associated degradation - تداخل وابسته به اندوپلاسمی رتیکولومTandem mass spectrometry - طیف سنجی جرمی پشت سر هم یا متوالیUbiquitin-like protein - پروتئین مانند پروتئین Ubiquitinsmall ubiquitin-like modifier - کوچک مانند ubiquitin مانند اصلاح کنندهUbiquitin - یوبیکویتین
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The dynamic and specific modification of cellular proteins by members of the ubiquitin protein family is a vital regulatory mechanism that lies at the heart of almost all biological processes. Because of both their pervasive and complex nature, these regulatory pathways have been the target of many recent proteomic studies. Such works have provided numerous insights. Through the use of various mass spectrometry techniques, affinity purification methods, and/or chemical probes, large lists have begun to be compiled for the multitude of substrates, interacting partners, and enzymatic components of these regulatory circuits. Furthermore, similar tools have provided many insights into functional aspects such as their mechanisms of substrate specificity and enzymatic activity. This review provides a summary of these recent proteomic works, along with comments on future directions of the field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 9, Issue 1, February 2005, Pages 69-75
Journal: Current Opinion in Chemical Biology - Volume 9, Issue 1, February 2005, Pages 69-75
نویسندگان
Carilee Denison, Donald S Kirkpatrick, Steven P Gygi,