Synthesis, characterization and cytotoxicity of a series of tetrachloridoplatinum(IV) complexes

► Synthesis of two new Pt(IV) derivatives. ► Characterization and structure determination by X-ray diffraction. ► The position of methyl group plays an important role in the cytotoxicity. ► The IC50 of new complexes were lower in comparison to cisplatin, especially in T47D.