The triphenyltin(VI) complexes of NSAIDs and derivatives. Synthesis, crystal structure and antiproliferative activity. Potent anticancer agents

The novel triphenyltin(IV)esters of flufenamic acid (1), Hflu, [Ph3Sn(flu)] (2), and of [2-(2,3-dichlorophenylamino)benzoic acid] (3), Hdcpa, [Ph3Sn(dcpa)] (4) have been characterized by spectroscopic studies. The crystal and molecular structures of [SnPh3(dcpa)(dmso)] is described. The in vitro cytotoxic activity of 1-4 and of the related NSAIDs has been evaluated against cancer cell lines MCF-7, T-24, A-549 and L-929. The results of this study represent the discovery of triphenyltin(IV)esters as a potential novel class of anticancer agents.