کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10574012 | 976488 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins](/preview/png/10574012.png)
چکیده انگلیسی
Truncated hemoglobins (trHbs) are low-molecular-weight oxygen-binding heme-proteins distributed in eubacteria, cyanobacteria, unicellular eukaryotes, and in higher plants, constituting a distinct group within the hemoglobin (Hb) superfamily. TrHbs display amino acid sequences 20-40 residues shorter than classical (non)vertebrate Hbs and myoglobins, to which they are scarcely related by sequence similarity. The trHb tertiary structure is based on a 2-on-2 α-helical sandwich, which represents a striking editing of the highly conserved 3-on-3 α-helical globin fold, achieved through deletion/truncation of α-helices and specific residue substitutions. Despite their 'minimal' polypeptide chain span, trHbs display an inner tunnel/cavity system held to support ligand diffusion to/from the heme distal pocket, accumulation of heme ligands within the protein matrix, and/or multiligand reactions. Moreover, trHbs bind and effectively stabilize the heme and recognize diatomic ligands (i.e., O2, CO, NO, and cyanide), albeit with varying thermodynamic and kinetic parameters. Here, structural bases for heme binding and diatomic ligand recognition by trHbs are reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 1, January 2005, Pages 97-109
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 1, January 2005, Pages 97-109
نویسندگان
Mario Milani, Alessandra Pesce, Marco Nardini, Hugues Ouellet, Yannick Ouellet, Sylvia Dewilde, Alessio Bocedi, Paolo Ascenzi, Michel Guertin, Luc Moens, Joel M. Friedman, Jonathan B. Wittenberg, Martino Bolognesi,