کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
105822 161522 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The epigenomics revolution in myelodysplasia: a clinico-pathological perspective
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
The epigenomics revolution in myelodysplasia: a clinico-pathological perspective
چکیده انگلیسی

SummaryRapid advances in molecular technologies are continually reshaping the way we view and understand the mechanisms driving oncogenesis. The last decade has witnessed unparalleled change in the biology and therapy of the myelodysplastic syndromes (MDS), a heterogeneous collection of clonal myeloid disorders characterised by ineffective haematopoiesis and susceptibility to acute leukaemia transformation. Pivotal studies demonstrating the positive effects of hypomethylating agents on clinical outcome have brought an ‘epigenomics revolution’ to this disease, emphasising the importance of epigenetic mechanisms to the underlying pathogenesis of MDS. One of the most important future challenges in the MDS field will be to determine whether epigenetic therapies can be made more ‘targeted’ through identification of biomarkers which define subsets of patients most likely to benefit from treatment. A wave of novel mutations have recently been reported in MDS and other myeloid disorders, several of which regulate endogenous methylation networks within cells (including TET2, DNMT3A, IDH and EZH2). The relevance of these lesions in being able to predict response to epigenetic modulators and their correlation with epigenetic signatures in MDS are beginning to emerge.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 43, Issue 6, October 2011, Pages 536-546