Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action

Ar = Ph; 2-, 3- and 4-substituted-phenyls with Me, CF3, halogens, alkyl, alkoxy, etc. KI (hCA I) >10 μM; KI (hCA II) >10 μM; KI (hCA IX) = 9.0-95.3 nM; KI (hCA XII) = 3.5-14.2 nM.