The synthesis and biological activity of novel anthracenone-pyranones and anthracenone-furans

An efficient and divergent methodology for the synthesis of new anthracenone-pyranones and anthracenone-furans is described as well as in vitro growth inhibition in a range of human cancer cells. The lead natural product BE-26554A displayed good cell growth activity on BE2-C neuroblastoma and SMA glioblastoma cell lines at 0.17, 0.16 μM (GI50), respectively. A CF3 functionalised anthracenone 4-pyranone (chromone) and an anthracenone-furan derivative which both displayed strong growth inhibition in the BE2-C neuroblastoma cell line are also discussed.64