Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1

Novel Western blot assay was developed and tested for its applicability in identifying radiosensitizers that target nucleophosmin 1 (NPM1). Extractability of pNPM1 was used as a measurement for identification of active compounds from a library of analogs synthesized based on the lead molecule, YTR107.115