Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors

The DXR inhibition potential of esters and sodium salts of aryl- and heteroarylcarbamoylphosphonic acids, with up to four methylene groups seperating the phosphonate and carboxamide moieties, have been explored using in silico docking, STD NMR and enzyme inhibition methods.