Isoxazole substituted chromans against oxidative stress-induced neuronal damage

In an effort to optimize our previously identified neuroprotective chroman derivatives, 20 new 2 or 5-substituted chroman analogues bearing isoxazole moieties with aliphatic or aromatic substituents were synthesized and their activity against oxidative stress-induced damage in neuronal HT22 cells was evaluated. The differences in activity observed between regioisomers were attributed to specific structural characteristics.