Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABAA receptors

2-Aryl-2,6-dihydro[1,2,4]triazolo[4,3-c]quinazoline-3,5-diones were designed based on a pharmacophore model, synthesized and evaluated for their affinity for the benzodiazepine binding site of GABAA receptors.