کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10582761 | 981101 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8â²-hydroxylase CYP707A
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8â²-hydroxylase CYP707A Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8â²-hydroxylase CYP707A](/preview/png/10582761.png)
چکیده انگلیسی
We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8â²-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 1, 1 January 2011, Pages 406-413
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 1, 1 January 2011, Pages 406-413
نویسندگان
Mariko Okazaki, Hataitip Nimitkeatkai, Taku Muramatsu, Hikaru Aoyama, Kotomi Ueno, Masaharu Mizutani, Nobuhiro Hirai, Satoru Kondo, Toshiyuki Ohnishi, Yasushi Todoroki,