Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor

The nature of substituents at the 7-position of 1-(3-bromophenylamino)isoquinoline-4-carbontriles modulates potency for MLCK and EGFR.