Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAFV600E inhibitors

To provide new therapeutic opportunities, a series of novel 4,5-dihydro-1H-pyrazole derivatives (6a-10d) containing thiazole moiety as potential V600E mutant BRAF kinase (BRAFV600E) inhibitors were designed and synthesized. All compounds were evaluated in vitro for anticancer activities against WM266.4 and MCF-7 cell line. Compound 10d displayed the most potential antiproliferative activity.