کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
105836 161523 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lobular neoplasia of the breast: 68 years on
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
Lobular neoplasia of the breast: 68 years on
چکیده انگلیسی

SummaryLobular neoplasia, which encompasses both atypical lobular hyperplasia and lobular carcinoma in situ, is traditionally considered a risk lesion that indicates an increased relative risk of the affected woman for subsequent breast cancer development. Recent molecular genetic information on this entity, however, has provided additional insights into the biology of this incompletely understood disease. Recognition of variants of lobular carcinoma in situ has also led to dilemmas in optimal management, and the advent of preoperative core biopsies for radiologically detected lesions has created uncertainties regarding how best to handle incidentally discovered lobular neoplasia on these biopsy cores. This article provides an overview of existing concepts, diagnostic pitfalls, pathobiology and current management approaches for this enigmatic lesion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 41, Issue 1, January 2009, Pages 28-35