کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10583729 | 981305 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines](/preview/png/10583729.png)
چکیده انگلیسی
The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Additionally, the compounds were screened against a variety of other microbial targets and as a result, selective activity against several fungi was also observed. The synthesis and preliminary biological results are reported herein.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 7, 1 April 2014, Pages 2113-2122
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 7, 1 April 2014, Pages 2113-2122
نویسندگان
Kartik W. Temburnikar, Sarah C. Zimmermann, Nathaniel T. Kim, Christina R. Ross, Christopher Gelbmann, Christine E. Salomon, Gerald M. Wilson, Jan Balzarini, Katherine L. Seley-Radtke,