Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles

Compounds 9a,b, 13a-d and 14a at a dose of 10 mg/kg showed very significant anticonvulsant activity and very significantly increased the latency time of PTZ-induced tonic seizures, and decreased the number of animals showing tonic seizures in response to PTZ injection.