Effect of dehydroepiandrosterone derivatives on the activity of 5α-reductase isoenzymes and on cancer cell line PC-3

- Derivatives having a chlorine and formyl substituent showed 5α-R2 inhibitory activity.
- Steroids with an imidazole and formyl groups exhibited 5α-R1 inhibitory activity.
- Compounds having an imidazole substituent at C-17 inhibited the cell growth of PC-3.