Design and syntheses of novel N′-((4-oxo-4H-chromen-3-yl)methylene)benzohydrazide as inhibitors of cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase

As potential inhibitors of Cy-FBP/SBPase, a series of novel type chromone-benzohydrazone derivatives were designed and synthesized. Amongst these compounds, the compound f7 exhibits the most potent inhibitory activity (IC50 = 11.2 μM). The probable binding mode of compound f7 was analyzed by molecular docking, as shown in Figure 1.