کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10584894 | 981355 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A second-generation series of substituted methylenecyclopropane nucleosides (MCPNs) has been synthesized and evaluated for antiviral activity against a panel of human herpesviruses, and for cytotoxicity. Although alkylated 2,6-diaminopurine analogs showed little antiviral activity, the compounds containing ether and thioether substituents at the 6-position of the purine did demonstrate potent and selective antiviral activity against several different human herpesviruses. In the 6-alkoxy series, antiviral activity depended on the length of the ether carbon chain, with the optimum chain length being about four carbon units long. For the corresponding thioethers, compounds containing secondary thioethers were more potent than those with primary thioethers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 12, 15 June 2012, Pages 3710-3718
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 12, 15 June 2012, Pages 3710-3718
نویسندگان
John D. Williams, Atiyya R. Khan, Emma A. Harden, Caroll B. Hartline, Geraldine M. Jefferson, Kathy A. Keith, Mark N. Prichard, Jiri Zemlicka, Norton P. Peet, Terry L. Bowlin,